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As the calendar turns to September, we enter the final stretch of the 2025 MLB regular season. And while it seems like this year’s postseason participants are pretty much set, there is still some jockeying for seeding left to be done. And there could still be a team that surprises us by sneaking into the postseason.

With that in mind, here are six series to keep an eye on over the regular season’s final month.

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New York Mets vs. Cincinnati Reds: Sept. 5-7

For more than two months, the same six teams have been in playoff position in the National League, but one team that has an outside shot to make things interesting over the final four weeks is the Cincinnati Reds. The team just ahead of them in the wild-card standings is the New York Mets, who lead by four games. Granted, four games is a significant lead at this point in the season, but a three-game series between these two squads makes that lead feel much smaller.

For the Reds, this series will be their last real opportunity to gain ground on the Mets and put some pressure on the team from Queens. For the Mets, a series victory and especially a sweep would essentially secure their wild-card berth and end the Reds’ hopes of getting to October.

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New York Yankees vs. Boston Red Sox: Sept. 12-14

Yes, baseball’s most famous rivalry is also a big series to watch in September, and it’s not just because these two storied franchises are facing off. The Red Sox and Yankees currently sit in the first and second AL wild-card spots, respectively. But with just a half-game separating them entering play Friday, the fight for seeding and home-field advantage in the first round is very much up for grabs.

One of the things that makes this series extra compelling is that the Yankees haven’t played well against their AL East rivals this season. Boston has an 8-2 record against New York this year, and with the Yanks having struggled in general lately, the Sox have all the momentum on their side entering the month of September. The winner of this series will likely be hosting the loser one month from now, with a trip to the ALDS on the line.

San Diego Padres vs. New York Mets: Sept. 16-18

The San Diego Padres are in an interesting position as the month of September begins. They have a solid hold of the NL’s second wild card, with a chance to pass the Cubs for the top spot, and they still have a shot at wresting the NL West title away from the L.A. Dodgers. That said, unfortunately for the Padres, when they had head-to-head opportunities to really make the Dodgers panic, they were unable to do so.

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Coming with less than two weeks left in the season, this series between the Padres and Mets will be pivotal for seeding in the NL wild card, and it represents a playoff stress test, with two potential postseason teams squaring off for three important games.

Chicago Cubs vs. Cincinnati Reds: Sept. 18-21

The Chicago Cubs have had an interesting season, to say the least. By record, they’re still one of the best teams in MLB. But because they haven’t exactly played their best baseball in the second half, it feels like they’re in a worse spot than they actually are. With that in mind, it would benefit the Cubs greatly to find some consistency before they get to October. And in the process, they could spoil their division-rival Reds’ playoff chances.

As mentioned above, every game the Reds play in the month of September will be important in their quest to make it to the postseason. With the Cubs being one of the three teams ahead of them in the NL wild-card picture, a series victory or a sweep of the Cubs would go a long way in boosting Cincy’s playoff chances.

Several division titles and final playoff seeding are still to be determined in the month of September. (Henry Russell/Yahoo Sports)

Seattle Mariners vs. Houston Astros: Sept. 19-21

Mariners versus Astros just might be the best series to watch in September. Not only is this a battle between division rivals, but there’s also a good chance that the winner of this series will be in the driver’s seat for the division title. Seattle hasn’t played as well of late and needs to find its footing before the playoffs. Meanwhile, Houston, which has dealt with more injuries than any other team in baseball, has started to get healthy at just the right time. With Yordan Álvarez back in the middle of the lineup and Carlos Correa playing well since his return to Houston, the Astros look scary once again.

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For Seattle, a series victory here could put them in position to achieve something they haven’t done in more than 20 years: Win a division title. For Houston, defeating the Mariners would almost certainly give them the inside track on their fifth straight AL West crown.

Los Angeles Dodgers vs. Seattle Mariners: Sept. 26-28

The Dodgers have had moments this season when they’ve looked unstoppable. But they’ve also had moments when you wonder how a team that cost so much to put together could look so mediocre. Despite all of that, they’ve been able to hold off the Padres and retain their NL West lead, with a two-game margin entering play Friday. Fast-forward to the final weekend of the season, and this series could be huge for the Dodgers. If San Diego stays close, victories over the Mariners could be the difference between L.A. winning another division title and settling for a wild card.

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The series will also be important for seeding in the postseason. Assuming the NL Central-leading Milwaukee Brewers stay in position as the No. 1 seed, L.A. will be trying to finish with a better record than the NL East-leading Philadelphia Phillies in order to secure a bye and avoid the wild-card round altogether.

Seattle’s most important remaining series is still the three-game set with Houston noted above. But if they are to hang on for a place in the postseason, finishing the season strong against a quality opponent would be huge for the Mariners’ momentum going into October.

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