Michigan vs. Oklahoma prediction, odds, time: 2025 college football Week 2 picks from proven model

The 15th-ranked Michigan Wolverines battle the 18th-ranked Oklahoma Sooners in a Big Ten-SEC Week 2 matchup on Saturday. Both teams won their season openers, with Michigan earning a 34-17 win over New Mexico, while Oklahoma defeated Illinois State 35-3. The Wolverines, who finished 8-5 overall in 2024, were 1-3 on the road last year. The Sooners, who were 6-7 last season, were 5-2 on their home field.

Kickoff is set for 7:30 p.m. ET at Gaylor Family Oklahoma Memorial Stadium in Norman, Okla. The Sooners are 5.5-point favorites in the latest Oklahoma vs. Michigan odds, while the over/under for total points scored is 44, down from opening at 53.5. Before making any Michigan vs. Oklahoma picks, check out the college football predictions from the SportsLine Projection Model.

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.  

Now, the model has set its sights on Michigan vs. Oklahoma. You can visit SportsLine now to see the picks. Here are the FBS college football lines and trends for Michigan vs. Oklahoma:

Why Oklahoma can cover

Former Washington State quarterback John Mateer has taken over the Sooners’ offense. The redshirt junior completed 30 of 37 passes (81.1%) for 392 yards and three touchdowns in the season opener. He also carried seven times for 24 yards and one score. For his career, he has completed 66.7% of his passes for 3,798 yards and 35 touchdowns, with nine interceptions and a rating of 170.1.

Senior wide receiver Keontez Lewis, who started his career at Wisconsin before moving on to Southern Illinois last year, had a productive start to his Sooners career. He caught a team-high nine passes for 119 yards (13.2 average) and two touchdowns in the opener. At Southern Illinois, he caught 49 passes for 790 yards (16.1 average) and five touchdowns. In the Salukis’ 62-0 win over Murray State on Nov. 23, he caught five passes for 104 yards and two touchdowns. See which team to back at SportsLine. 

Why Michigan can cover

Freshman Bryce Underwood is the Wolverines’ starting quarterback. In the win over New Mexico, he completed 21 of 31 passes (67.7%) for 251 yards and one touchdown. He will face his biggest test of his young career when he faces the Sooners on the road. He was a four-year starter in high school, compiling a 50-4 record and earning two Division 1 state championships, while at Belleville High School in Detroit.

Junior running back Justice Haynes is also a big part of the Wolverines’ offense. The transfer from Alabama carried 16 times for 159 yards and three touchdowns in the Week 1 win. In his three-year collegiate career, he has 120 carries for 775 yards (6.5 average) and 12 touchdowns. Last season with the Crimson Tide, he rushed for 448 yards on 79 carries (5.7 average) and seven touchdowns. See which team to back at SportsLine.

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How to make Michigan vs. Oklahoma picks

SportsLine’s model is leaning over on the total. It has also generated an against-the-spread pick that hits in well over 60% of simulations. You can only get the pick at SportsLine. 

So who wins Michigan vs. Oklahoma, and which side of the spread cashes in well over 60% of simulations? Visit SportsLine now to see which side of the Michigan vs. Oklahoma spread to jump on, all from the advanced model that finished up over $2,000 on its FBS college football picks since its inception, and find out.