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It’s Tuesday, April 29 and the Giants (19-10) are in San Diego to take on the Padres (17-11). Logan Webb is slated to take the mound for San Francisco against Nick Pivetta for San Diego.

The Giants and Padres both had an off day on Monday, so the bullpens should be fresher entering this matchup. San Francisco is coming off a walk-off little-league home run in the 9th inning on Sunday to beat the Rangers (3-2) in their last start. For San Diego, the Padres have lost four straight games, including a series sweep capped off by a 4-2 loss to the Rays on Sunday.

Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Giants at Padres

  • Date: Tuesday, April 29, 2025
  • Time: 9:40 PM EST
  • Site: Petco Park
  • City: San Diego, CA
  • Network/Streaming: NBCSBA, SDPA

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Giants at the Padres

The latest odds as of Tuesday:

  • Moneyline: Giants (-126), Padres (+106)
  • Spread: Giants -1.5
  • Total: 6.0 runs

Probable starting pitchers for the Giants at Padres

  • Pitching matchup for April 29, 2025: Logan Webb vs. Nick Pivetta
    • Giants: Logan Webb, (3-1, 1.98 ERA)
      Last outing: 6.1 Innings Pitched, 0 Earned Runs Allowed, 6 Hits Allowed, 3 Walks, and 6 Strikeouts
    • Padres: Nick Pivetta, (4-1, 1.20 ERA)
      Last outing: 7.0 Innings Pitched, 0 Earned Runs Allowed, 2 Hits Allowed, 2 Walks, and 6 Strikeouts

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Expert picks & predictions for tonight’s game between the Giants and the Padres

Rotoworld Best Bet

Vaughn Dalzell (@VmoneySports) leans the No Runs First Innings (NRFI):

“This game has a lowly total of 6.5 — the lowest on the board today. With that in mind, I have to lean toward no runs to be scored in the first inning. The NRFI is 4-2 in Webb’s six starts this season and 4-1 in Pivetta’s five starts, including four consecutive winners. I will buy into that trend and the low total for a -135 price on the NRFI as a fun sweat.”

Top betting trends & insights to know ahead of Giants at Padres

  • The Padres have won 3 straight matchups against NL West teams
  • 9 of the Padres’ last 11 home games stayed under the Total
  • The Padres have failed to cover the Run Line in 7 of their last 9 games

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Tuesday’s game between the Giants and the Padres:

  • Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the San Diego Padres at +1.5.
  • Total: NBC Sports Bet is recommending a play on the over on the Game Total of 6.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.

Follow our experts on socials to keep up with all the latest content from the staff:

  • Jay Croucher (@croucherJD)
  • Drew Dinsick (@whale_capper)
  • Vaughn Dalzell (@VmoneySports)
  • Brad Thomas (@MrBradThomas)



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