Nearly half of the SEC has a bye this Saturday, meaning you’ll have to focus your Week 6 college football bets on others. There are still compelling SEC matchups like Alabama vs. Vanderbilt (+10.5) and Texas vs. Florida (+6.5) to make college football picks on, but the ACC also has a pair of interesting contests. That includes one of the sport’s best rivalries in Miami vs. Florida State, which has the No. 3 Hurricanes as 10-point favorites over the No. 18 Seminoles, per the Week 6 college football odds.
Another ACC contest has lots of star power — on the sideline — as Bill Belichick and Dabo Swinney meet for the first time, with their respective teams both coming off byes. Clemson is favored by 14 points over UNC in the latest Week 6 college football lines as the Tigers look for their first cover of the season. Before locking in any Week 6 college football picks on those games or others, be sure to see the latest Week 6 college football predictions from SportsLine’s proven model.
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college football spread picks, and is a profitable 35-22 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, it has turned its attention to the latest college football odds and Week 6 college football betting lines on the spread, money line, and over/under. Head here to see every pick.
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Top college football predictions for Week 6
One of the college football picks the model is high on during Week 6: Louisville (-7, 62.5) covers versus No. 24 Virginia in a 3:30 p.m. ET Saturday kickoff. The Cardinals have won seven straight games, which is tied for the fourth-longest streak in the nation, and they’re coming off a complete team victory over Pitt. QB Miller Moss had over 300 passing yards and three touchdowns, while the Cardinals defense forced five turnovers. Taking care of the ball is an issue for UVA, which had three giveaways in its last game, as the Cavaliers have won the turnover battle just once over their last four games. Virginia also gave up 256 rushing yards last week — its most since the 2023 season — and the team has lost three straight road games as the model has Louisville covering well over 60% of the time. See which other picks the model likes here.
Another prediction: No. 9 Texas (-6.5, 43.5) covers against Florida in well over 60% of simulations on Saturday at 3:30 p.m. ET. The Longhorns will visit The Swamp, but Texas is 9-1 on the road since 2023, the second-best away record in FBS over that span. Arch Manning has 13 total touchdowns (8 passing, 5 rushing) since Week 2, which leads the SEC over this stretch, despite Texas just coming off a bye. Meanwhile, Florida ranks last in the SEC with 22 points per game, and the Gators are 2-8 versus top-10 teams under Billy Napier. The Longhorns are undefeated in four all-time games versus Florida, as in addition to backing UT to cover, the SportsLine model also forecasts the Over hitting more than 50% of the time. See the rest of the model’s picks here.
How to make college football picks for Week 6
The model has also made the call on who wins and covers in every FBS matchup in Week 6, and it’s calling for multiple underdogs to win straight-up. You can only get every pick for every game at SportsLine, and for a limited time you can use promo code CHAMPIONSHIP to get your first month at SportsLine for $1.
So what college football picks can you make with confidence, and which underdogs win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.
Week 6 college football odds for notable games
See full Week 6 college football picks, odds, predictions here
(odds subject to change)
Thursday, Oct. 2
Sam Houston vs. New Mexico State (+2.5, 52.5)
Friday, Oct. 3
Charlotte vs. South Florida (-26.5, 54.5)
West Virginia vs. BYU (-19.5, 47.5)
Saturday, Oct. 4
Kentucky vs. Georgia (-20.5, 48.5)
Wisconsin vs. Michigan (-16.5, 42.5)
Air Force vs. Navy (-10.5, 49.5)
Clemson vs. North Carolina (+14, 45.5)
Texas vs. Florida (+6.5, 43.5)
Boise State vs. Notre Dame (-19.5, 65.5)
Virginia vs. Louisville (-7, 62.5)
Vanderbilt vs. Alabama (-10.5, 57)
Miami vs. Florida State (+4.5, 54.5)
Minnesota vs. Ohio State (-23.5, 44.5)
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