After a thrilling opening weekend, the Week 2 college football schedule features just one Top 25 showdown. The No. 18 Oklahoma Sooners host the No. 15 Michigan Wolverines at OU Memorial Stadium on Saturday at 7:30 p.m. ET. The Sooners opened the season with a 35-3 victory over Illinois State, while Michigan cruised to a 34-17 win over New Mexico. According to the latest Week 2 college football odds, the Sooners are favored by 5.5 points, while the over/under for total points scored is 46. SportsLine’s model is backing Michigan, which is 12-3 in its last 15 games on the road, to cover the spread in over 60% of simulations on Saturday.
The model is also backing Duke (+3) to cover at home against Illinois, while the Over (47.5) hits more than 60% of the time in Vanderbilt vs. Virginia Tech. Before locking in your Week 2 college football picks, be sure to check out the top college football betting picks from SportsLine’s proven computer model. New users can also use the latest bet365 bonus code to receive $300 in bonus bets instantly after your first $5 wager, and take advantage of one of the best sportsbook promos:
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns, and new users can also target the DraftKings promo code, which offers $300 in bonus bets instantly plus over $200 off NFL Sunday Ticket:
Week 2 college football best bets for Saturday, Sept. 6 (odds subject to change):
- Michigan (+5.5) vs. Oklahoma (-110)
- Duke (+3) vs. Illinois (-110)
- Over 47.5 points in Vanderbilt vs. Virginia Tech (-110)
Combining the model’s three picks into a Week 2 college football parlay would result in a payout of +596 (risk $100 to win $596).
Michigan +5.5 vs. Oklahoma
The Wolverines typically get off to fast starts, having won 17 of their last 18 games played in September. Oklahoma, meanwhile, is 2-4 against the spread in its last six games when playing as the favorite. The Wolverines will look to control the clock by imposing their dominant ground game, which was on full display in last week’s win over Nex Mexico. Running back Justice Haynes recorded 16 carries for 159 yards and three scores against the Lobos, and SportsLine’s model expects he’ll average 6.1 yards per carry against the Sooners. The model is projecting Michigan to cover the spread in over 60% of simulations, providing clear value on the spread.
Duke +3 vs. Illinois
Duke has the opportunity to make a statement with an early-season victory over a Fighting Illini team that many think can make an appearance in the College Football Playoff. The Blue Devils notched a 45-17 win over Elon in Week 1, strengthening their impressive home record. Duke enters Saturday’s showdown having won nine of its last 10 games at home, and the Blue Devils are 6-0 against the spread in their past six meetings against an opponent from the Big Ten. SportsLine’s model is backing Duke to cover the spread in 58% of simulations, targeting the Blue Devils as one of its top Week 2 college football picks.
Over 47.5 points in Vanderbilt vs. Virginia Tech
The Commodores racked up 45 points in last week’s win over Charleston Southern behind a strong showing from quarterback Diego Pavio, who completed 20 of 25 passes for 275 yards and three touchdowns. Pavio’s production is a big reason why the total has gone Over in five of Vanderbilt’s last five games played in September. The Over has also hit in eight of Vanderbilt’s past nine meetings against an opponent from the ACC. Vanderbilt secured a 34-27 win over Virginia Tech last season, and SportsLine’s model is projecting these two teams will combine for 55 points on Saturday, helping the Over hit in more than 60% of simulations.
Want more Week 2 college football picks?
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Also at SportsLine:
You can also see Week 2 college football picks from insider Thomas Casale. Visit SportsLine to see his best bets. SportsLine’s Tom Fornelli, who is 4-1 in his last five CFB ATS picks, has locked in his best bets for Week 2 right here.
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