Oregon vs. Oklahoma State prediction, odds, time: 2025 college football Week 2 picks by proven model

Teams looking to start the season 2-0 meet when the Oklahoma State Cowboys take on the sixth-ranked Oregon Ducks in a Week 2 college football non-conference matchup on Saturday on CBS and Paramount+. Oregon is coming off a 59-13 win over Montana State in the season opener, while Oklahoma State downed Tennessee-Martin 27-7. The Cowboys, who were 3-9 overall and 0-9 in the Big 12 last season, were 1-5 on the road in 2024. The Ducks, who were 13-1 a year ago, are 20-1 on their home field over the past three-plus seasons.    

Kickoff from Autzen Stadium in Eugene, Ore., is at 3:30 p.m. ET. Oregon won the only previous meeting with Oklahoma State, earning a 42-31 win in 2008. The Ducks are 27.5-point favorites in the latest Oregon vs. Oregon State odds, while the over/under for total points scored is 55.5. Before making any Oklahoma State vs. Oregon picks, check out the college football predictions from the SportsLine Projection Model. 

New users can also target the DraftKings promo code, which offers $300 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Be sure to watch this game on CBS and Paramount+, where new users can get a free one-week trial. Sign up here.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.  

Now, the model has set its sights on Oklahoma State vs. Oregon. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Oregon vs. Oklahoma State:

Why Oregon can cover

In his first start for the Ducks, redshirt sophomore quarterback Dante Moore completed 18 of 23 passes for 213 yards and three touchdowns in the win over Montana State. He also rushed three times for 18 yards. Moore began his collegiate career in 2023 at UCLA. That season, he completed 114 of 213 passes for 1,610 yards and 11 touchdowns with nine interceptions. Last year, in limited action for the Ducks, he completed 7 of 8 passes for 49 yards.

Also helping power the Oregon attack is sixth-year senior running back Noah Whittington. In the Week 1 win, he carried 10 times for 68 yards and one touchdown. Since beginning his career at Western Kentucky in 2020, he has rushed 404 times for 2,189 yards (5.4 average) and 16 touchdowns. Last season for the Ducks, he carried 118 times for 540 yards (4.6 average) and six touchdowns. See which team to back at SportsLine. 

Why Oklahoma State can cover

Redshirt freshman Zane Flores takes over at quarterback in a revamped Cowboys offense. In last week’s win over Tennessee-Martin, Flores completed 13 of 20 passes for 136 yards, while rushing three times for eight yards. He is in his third collegiate season, but had been dealing with injury concerns all of last year. He was the 2022 MaxPreps Nebraska Player of the Year after leading his team to the Class A state championship game, where he threw for 414 yards and three touchdowns.

Redshirt sophomore Kalib Hicks is another big part of Oklahoma State’s offense. He was the team’s workhorse a week ago, rushing 21 times for 56 yards. This is his first year with the program after spending two seasons at Oklahoma before entering the transfer portal. He played in seven games for the Sooners, carrying five times for 25 yards and one touchdown. See which team to back at SportsLine, and new users can also check out the latest bet365 bonus code to get $300 in bonus bets after placing a $5 bet:

How to make Oklahoma State vs. Oregon picks

SportsLine’s model is going Over on the total, projecting 68 combined points. It also says one side of the spread hits in nearly 60% of simulations. You can only get the pick at SportsLine. 

So who wins Oklahoma State vs. Oregon, and which side of the spread cashes in nearly 60% of simulations? Visit SportsLine now to see which side of the Oklahoma State vs. Oregon spread to jump on, all from the advanced model that finished up over $2,000 on its FBS college football picks since its inception, and find out.