Knockout stage is here! All about the Libertadores last 16

The Copa Libertadores knockout stage begins this Tuesday (10), starting to shape the road to Eternal Glory.

The round of 16 features six Brazilian clubs. And two of them will already face each other over the next two weeks.

Flamengo and Cruzeiro are involved in the only tie this round featuring two teams that have already won the tournament.

Here, OneFootball runs through the main details of each matchup. Check out the details below and leave your prediction in the comments on who will advance:

🇦🇷 Estudiantes x Universidad Católica 🇨🇱

First leg: 11/08 (Tuesday) at 9:30 p.m. at Estadio Ciudad de la Plata, in Argentina

Second leg: 18/08 (Tuesday) at 9:30 p.m. at Claro Arena, in Chile

Estudiantes: 2nd in Group A, with 9 points

Universidad Católica: 1st in Group D, with 13 points

– The clubs’ only meeting in Libertadores history came in the semifinals of the 1969 edition, with Estudiantes advancing to the final

– Católica won all three of their away matches in the group stage, including against Cruzeiro at Mineirão and Boca Juniors at La Bombonera

🇦🇷 Rosario Central x Corinthians 🇧🇷

First leg: 13/08 (Thursday) at 9:30 p.m. at Gigante de Arroyito, in Argentina

Second leg: 20/08 (Thursday) at 9:30 p.m. at Neo Química Arena

Rosario Central: 2nd in Group H, with 13 points

Corinthians: 1st in Group E, with 11 points

– If Depay really renews his contract with Timão, he could face Ángel Di María in a meeting of veterans with World Cup history. Both played in the 2014 World Cup in Brazil

– The clubs’ only clashes in Libertadores history came in the 2000 round of 16, when Corinthians advanced on penalties

🇧🇷 Cruzeiro x Flamengo 🇧🇷

First leg: 12/08 (Wednesday) at 9:30 p.m., at Mineirão

Second leg: 19/08 (Wednesday) at 9:30 p.m., at the Maracanã

Cruzeiro: 2nd in Group D, with 11 points

Flamengo: 1st in Group A, with 16 points

– The defending champions Flamengo did not sign any reinforcements for this round, while Cruzeiro have six new names in the squad: left-back Gabriel Rojas, defensive midfielder Zé Lucas, and forwards João Costa, Lucho Rodríguez, Wesley, and Gabriel Pec (the latter has not yet been registered for the Libertadores due to injury)

– It is the only round-of-16 tie between clubs that have already won the Libertadores

🇨🇴 Tolima x Independiente del Valle 🇪🇨

First leg: 11/08 (Tuesday) at 9:30 p.m. at Estadio Manuel Murillo Toro, in Colombia

Second leg: 18/08 (Tuesday) at 9:30 p.m. at Estadio Banco de Guayaquil, in Ecuador

Tolima: 2nd in Group B, with 8 points

Independiente del Valle: 1st in Group H, with 13 points

– The only tie in this round of 16 without a team from Brazil or Argentina

– Del Valle is the team with the most shots in this Libertadores edition, but has “only” the second-highest number of goals scored, tied with Flamengo (11)

🇧🇷 Mirassol x LDU 🇪🇨

First leg: 13/08 (Thursday) at 7 p.m. at Maião

Second leg: 20/08 (Thursday) at 7 p.m. at Estadio Rodrigo Paz Delgado, in Ecuador

Mirassol: 2nd in Group G, with 12 points

LDU: 1st in Group G, with 12 points

– It is one of the three round-of-16 ties in which the teams already faced each other in the group stage. Both matches ended 2-0 to the home side

– Brazilian Tiago Nunes was LDU’s coach in the group-stage meetings, but he was sacked in July

🇧🇷 Palmeiras x Cerro Porteño 🇵🇾

First leg: 12/08 (Wednesday) at 7 p.m. at Nubank Parque

Second leg: 19/08 (Wednesday) at 7 p.m. at Estadio General Pablo Rojas, in Paraguay

Palmeiras: 2nd in Group F, with 11 points

Cerro Porteño: 1st in Group F, with 13 points

– It is one of the three round-of-16 ties in which the teams already faced each other in the group stage. There was a draw in Asunción and a Cerro win in São Paulo

– The clubs will reach 20 Libertadores matches between them. This is the most frequently repeated matchup in the tournament’s history between teams from different countries

🇦🇷 Platense x Coquimbo Unido 🇨🇱

First leg: 12/08 (Wednesday) at 7 p.m. at Estadio Ciudad de Vicente Lopez, in Argentina

Second leg: 19/08 (Wednesday) at 7 p.m. at Estadio Francisco Sánchez Rumoroso, in Chile

Platense: 2nd in Group E, with 10 points

Coquimbo Unido: 1st in Group B, with 10 points

– The only tie this round featuring two teams that have never played in a Libertadores final

– Both clubs won their countries’ national titles for the first time in 2025

🇧🇷 Fluminense x Independiente Rivadavia 🇦🇷

First leg: 11/08 (Tuesday) at 7 p.m. at the Maracanã

Second leg: 18/08 (Tuesday) at 7 p.m. at Estadio Malvinas Argentinas, in Argentina

Fluminense: 2nd in Group C, with 8 points

Independiente Rivadavia: 1st in Group C, with 16 points

– It is one of the three round-of-16 ties in which the teams already faced each other in the group stage. Tricolor drew in Argentina and lost in Rio

– Rivadavia has the Libertadores top scorer, Alex Arce, with eight goals. Flu’s top scorer in the tournament is injured: John Kennedy, with just two goals

This article was translated into English by Artificial Intelligence. You can read the original version in 🇧🇷 here.

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