It’s Wednesday, August 20 and the Giants (61-64) are in San Diego to take on the Padres (69-56). Landen Roupp is slated to take the mound for San Francisco against JP Sears for San Diego.
The Padres snapped a four-game losing streak with a 5-1 win over the Giants to make this four-game series a little more interesting. San Diego is now 4-1 versus San Francisco over the last 10 days, but 1-4 since the three-game set with the Giants.
Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Giants at Padres
- Date: Wednesday, August 20, 2025
- Time: 9:40 PM ET
- Site: Petco Park
- City: San Diego, CA
- Network/Streaming: NBCSBA, SDPA, MLBN
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Giants at the Padres
The latest odds as of Wednesday:
- Moneyline: Giants (+190), Padres (-232)
- Spread: Padres -1.5
- Total: 8.0 runs
Probable starting pitchers for Giants at Padres
- Pitching matchup for August 20, 2025: Landen Roupp vs. JP Sears
- Giants: Landen Roupp, (7-6, 3.45 ERA)
Last outing: 15.00 ERA, 5 Earned Runs Allowed, 5 Hits Allowed, 1 Walks, and 5 Strikeouts - Padres: JP Sears, (7-10, 9.00 ERA)
Last outing: 9.00 ERA, 5 Earned Runs Allowed, 10 Hits Allowed, 1 Walks, and 4 Strikeouts
- Giants: Landen Roupp, (7-6, 3.45 ERA)
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Top betting trends & insights to know ahead of Giants at Padres
- The Giants are 2-8 in the last 10 games
- The Padres are 1-4 in the last 5 games
- San Diego is 8-3 versus San Francisco this season
- Each of the Padres’ last 4 home games against the Giants have gone over the Total
- The Padres have covered in 4 of their last 5 games for a profit of 1.74 units
- The Padres have won 4 of their last 5 games at home against National League teams
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Expert picks & predictions for tonight’s game between the Giants and the Padres
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Wednesday’s game between the Giants and the Padres:
- Moneyline: NBC Sports Bet is recommending a play on the San Diego Padres on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the San Francisco Giants at +1.5.
- Total: NBC Sports Bet is staying away from a play on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
Follow our experts on socials to keep up with all the latest content from the staff:
- Jay Croucher (@croucherJD)
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- Vaughn Dalzell (@VmoneySports)
- Trysta Krick (@Trysta_Krick)
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