The 2025 college football season has returned, and fans should use the latest DraftKings promo code, offering over $200 off on NFL Sunday Ticket as well as $200 in bonus bets. Several matchups like Iowa State vs. Kansas State in Dublin at noon ET, Fresno State vs. Kansas, and Stanford vs. Hawaii are kicking off on Saturday. That’s why DraftKings is the perfect outlet to get you prepared for this Week 0 slate of college football. Kansas is favored by 13.5 points in the latest Week 0 college football odds, while Kansas State is a 3-point favorite over Iowa State.
The model is taking Iowa State on the money line (+130) as one of its top college football predictions this week. Before locking in your Week 0 college football picks on your favorite betting sites like DraftKings, you’ll also want to be sure to check out the top college football betting picks from SportsLine’s proven computer model. Claim the latest DraftKings bonus code here, where new users get $200 in bonus bets, in addition to more than $200 off NFL Sunday Ticket:
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks on betting sites could have seen strong returns.
Best Week 0 college football picks:
- Iowa State (+3) vs. Kansas State (-105)
- Fresno State +13.5 vs. Kansas (-115)
- Stanford moneyline (+114) vs. Hawaii
Combining the model’s three picks into a Week 0 college football parlay at DraftKings would result in a payout of +681 (risk $100 to win $681). Bet it at DraftKings here:
Iowa State (+3) vs. Kansas State
In this top 25 Big 12 showdown to start the season, the model expects a strong start from the Cyclones. Iowa State has defeated Kansas State in four of the last five meetings. Quarterback Rocco Becht returns for Iowa State after tossing 3,505 passing yards and 25 passing touchdowns. On the Wildcats’ sideline, Avery Johnson threw for 2,712 passing yards and 25 touchdowns. Despite both quarterbacks being some of the best in the conference, the model has the Cyclones covering the spread in well over 50% of the simulations.
Fresno State +13.5 vs. Kansas (-115)
Fresno State is rolling out E.J. Warner, the son of Hall of Famer Kurt Warner, as its starting quarterback on Saturday. Warner won a three-way battle for the starting job after transferring from Rice for his senior season. While turnovers have been an issue for him, he also racked up 58 passing touchdowns over the past three seasons. Kansas got off to a bad start last season, and the model has the Jayhawks coming up short of covering the spread on Saturday, as Fresno State is covering in well over 50% of simulations.
Stanford moneyline (+114) vs. Hawaii
The Stanford Cardinal went 3-9 last season, and they hired Andrew Luck as the interim GM in November 2024. That led to them hiring Frank Reich as the head coach. Meanwhile, the Hawaii Rainbow Warriors went 5-7 last season and haven’t been bowl-eligible since 2019. Timmy Chang goes into his fourth season with Hawaii and owns a 13-25 record. Stanford has 11 starters returning, and the model projects the Cardinal to win in almost 60% of simulations.
Want more Week 0 college football picks?
You’ve seen the model’s Week 0 college football best bets. Now, get against the spread, total and money-line picks for every Week 0 CFB game here, all from the model that’s simulated every game 10,000 times.
Also at SportsLine:
You can also see Week 0 college football picks from former Vegas bookmaker Micah Roberts. Visit SportsLine to see his best bets. SportsLine’s Josh Nagel, who is 4-0 in his last four spread picks involving Kansas State, has locked in his best bet for Iowa State vs. Kansas State right here.
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