Cubs vs White Sox Prediction: Odds, recent stats, trends, and best bets for August 18

Pete Crow-Armstrong hammered a walk-off two-run homer in the bottom of the 10th inning to seal a 7-5 Cubs (73-53) win over the White Sox (65-59) and push him ahead as the favorite in the National League MVP race. The season series between the Cubs and White Sox is tied at two apiece with two games remaining.

The loss snapped a three-game winning streak for the White Sox. Over the past week, Chicago’s pitching staff has a 4.33 ERA (14th), which has been nullified by the hot bats on offense. The White Sox are hitting .280 over the past six days (5th) and an MLB-best 11 home runs.

The Cubs walk-off winner was an MLB-tying 11 home runs in the past week. Chicago’s scored 30 runs in that span (T-6th), which trails a few teams such as the White Sox who are in first with 38 runs. However, the Cubs pitching rotation has the second-worst ERA (6.00) in the last six games.

Let’s dive into tonight’s matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch White Sox at Cubs

Date: Tuesday, August 18, 2026
Network/Streaming: MLB TV / TBS

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Odds for the White Sox at the Cubs

The latest odds as of Tuesday:

Moneyline: Chicago Cubs (-168), Chicago White Sox (+157)
Spread: White Sox +1.5 (-144), Cubs -1.5 (+119)

Probable starting pitchers for White Sox at Cubs

2026 stats: 51.2 IP, 3-4, 3.14 ERA, 1.28 WHIP, 50 K, 17 BB

2026 Stats: 139.0 IP, 6-11, 4.53 ERA, 1.27 WHIP, 138 K, 38 BB

Who’s Hot? Who’s Not

Pete Crow-Armstrong is hitting .273 in August (18/66) with six home runs and 15 RBI
Alex Bregman is hitting .306 in August (19/62) with five home runs and 14 RBI
Seiya Suzuki is hitting .288 in August (17/59) with four home runs and 14 RBI
Colson Montgomery is hitting .179 in August (10/56) with 26 strikeouts and four walks

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Top betting trends & insights to know ahead of White Sox at Cubs

The White Sox are an MLB-best 74-50 ATS
The Cubs are 67-56-2 to the Over, ranking sixth-best
The White Sox are an MLB-best 71-51-2 to the Over
The Cubs are 27-35 ATS at home, ranking fifth-worst
The White Sox are 35-27 ATS on the road, ranking fifth-best

Expert picks & predictions for tonight’s game between the White Sox and the Cubs

Rotoworld Bet Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Tuesday’s game between the Cubs and the White Sox:

Moneyline: NBC Sports Bet is recommending a play on the White Sox on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the White Sox at +1.5.
Total: NBC Sports Bet is recommending a play on the Under on the Game Total of 9.0

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