Astros vs. Blue Jays prediction: Odds, recent stats, trends, and best bets for June 22

The Houston Astros (37-42) open a three-game set in Toronto (38-39) tonight. The Astros took two of three over the weekend against Cleveland and have now won four of their last five to pull within three games of first in the American League West and within two of the final Wild Card spot. Toronto was rained out yesterday in Chicago after splitting the first two games of that series. The Jays have now won four of their last five games and sit 8.5 games in back of the Yankees in the AL East but in that aforementioned third and final Wild Card spot.

Toronto has been solid at home (21–18), while Houston has struggled on the road at 17–21.

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The pitching matchup tonight features a pair of staff aces as Hunter Brown takes the ball for the ‘Stros against Dylan Cease of the Jays. Brown will be making his second start for Houston since returning from the disabled list. He is 1–0 with a sparkling 1.10 ERA with 24 strikeouts across just over 16 innings. The Blue Jays were expected to counter with right-hander Shane Bieber, but due to yesterday’s postponement, Bieber has been pushed back a day and Cease will start. This will be Cease’s 14^th start of the season. He is 4-3 with a 2.71 ERA and 110 strikeouts (third in MLB).

Houston’s offense centers around their Triple Crown candidate, Yordan Alvarez. The designated hitter ranks fourth in the game with a .322 average, second with 25 home runs, and fifth in baseball with 56 RBIs. Ernie Clement struggled over the weekend but leads the Jays with a .292 average. Kyle Okamoto strikes out about once every three at bats but does damage when he makes contact with a team-leading 16 home runs.

Lets dive into tonight’s matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game Details and How to Watch: Astros vs. Blue Jays

• Date: Monday, June 22, 2026

• Network/Streaming: MLB.TV, Sportsnet, SCHN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

The Latest Odds: Astros vs. Blue Jays

The latest odds as of Monday courtesy of DraftKings:

• Moneyline: Houston Astros (+104), Toronto Blue Jays (-126)

• Spread: Astros +1.5 (-206), Blue Jays -1.5 (+168)

Probable Starting Pitchers and their Stats: Astros vs. Blue Jays for June 22

• Astros: Hunter Brown
  Season Totals: 16.1 IP, 1-0, 1.10 ERA, 1.04 WHIP, 24K, 9 BB

• Blue Jays: Dylan Cease
  Season Totals: 73.0 IP, 4-3, 2.71 ERA, 1.19 WHIP, 110K, 31 BB

Who’s Hot? Who’s Not! Astros vs. Blue Jays

• Cam Smith was 1-9 over the weekend against Cleveland

• Vlad Guerrero Jr. has hit safely in 3 of his last 4 games (5-15)

• Ernie Clement is 1-15 over his last 4 games

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

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Top Betting Trends & Insights: Astros vs. Blue Jays

• The Jays are 37-40 on the Run Line this season

• The Astros are 37-42 on the Run Line this season

• The OVER has cashed 42 times in Houston’s 79 games this season (42-34-3)

• The OVER has cashed 38 times in the Toronto’s 77 games this season (38-35-4)

Expert picks & predictions: Astros vs. Blue Jays

Rotoworld Bet Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

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Here are the best bets our model is projecting for today’s game between the Astros and the Blue Jays:

• Moneyline: Rotoworld Bet is leaning towards a play on the Astros on the Moneyline.

• Spread: Rotoworld Bet is staying away from a play on the Run Line.

• Total: Rotoworld Bet is leaning towards a play on the Game Total OVER 7.5

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