Its Wednesday, April 16 and the Astros (8-9) are in St. Louis to take on the Cardinals (8-9).
Ronel Blanco is slated to take the mound for Houston against Steven Matz for St. Louis.
The Astros beat the Cardinals last night 2-0, thanks to a run in the sixth and eighth innings. Hunter Brown was dealing. He picked up the win and pitched six shutout innings.
Last night was the first shutout for the Astros this season. They look to use that momentum to push a few wins together.
Lets dive into the matchup and find a sweat or two.
We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Astros at Cardinals
- Date: Wednesday, April 16, 2025
- Time: 1:15PM EST
- Site: Busch Stadium
- City: St. Louis, MO
- Network/Streaming: FanDuel Sports Midwest, Space City Home Network
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Astros at the Cardinals
The latest odds as of Wednesday:
- Moneyline: Astros (-113), Cardinals (-106)
- Spread: Astros -1.5
- Total: 8.0 runs
Probable starting pitchers for Astros at Cardinals
- Pitching matchup for April 16, 2025: Ronel Blanco vs. Steven Matz
- Astros: Ronel Blanco, (1-1, 6.94 ERA)
Last outing: 5.0 Innings Pitched, 2 Earned Runs Allowed, 5 Hits Allowed, 1 Walks, and 7 Strikeouts - Cardinals: Steven Matz, (0-0, 2.31 ERA)
Last outing: 2.1 Innings Pitched, 1 Earned Runs Allowed, 5 Hits Allowed, 1 Walks, and 1 Strikeouts
- Astros: Ronel Blanco, (1-1, 6.94 ERA)
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Top betting trends & insights to know ahead of Astros at Cardinals
- The Astros have won 12 of their last 20 away games against teams with losing records
- In his last 5 starts on the mound the Cardinals pitcher Steven Matz has an ERA of 8.74
- The Cardinals have covered in 4 of their last 5 home games with Steven Matz as starting pitcher to return 3.78 units
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Expert picks & predictions for tonight’s game between the Astros and the Cardinals
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Wednesday’s game between the Astros and the Cardinals:
- Moneyline: NBC Sports Bet is recommending a play on the Houston Astros on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the St. Louis Cardinals at +1.5.
- Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC
Follow our experts on socials to keep up with all the latest content from the staff:
- Jay Croucher (@croucherJD)
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- Vaughn Dalzell (@VmoneySports)
- Brad Thomas (@MrBradThomas)
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