The Copa Libertadores knockout stage begins this Tuesday (10), starting to shape the road to Eternal Glory.
The round of 16 features six Brazilian clubs. And two of them will already face each other over the next two weeks.
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Flamengo and Cruzeiro are involved in the only tie this round featuring two teams that have already won the tournament.
Here, OneFootball runs through the main details of each matchup. Check out the details below and leave your prediction in the comments on who will advance:
🇦🇷 Estudiantes x Universidad Católica 🇨🇱
First leg: 11/08 (Tuesday) at 9:30 p.m. at Estadio Ciudad de la Plata, in Argentina
Second leg: 18/08 (Tuesday) at 9:30 p.m. at Claro Arena, in Chile
Estudiantes: 2nd in Group A, with 9 points
Universidad Católica: 1st in Group D, with 13 points
– The clubs’ only meeting in Libertadores history came in the semifinals of the 1969 edition, with Estudiantes advancing to the final
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– Católica won all three of their away matches in the group stage, including against Cruzeiro at Mineirão and Boca Juniors at La Bombonera
🇦🇷 Rosario Central x Corinthians 🇧🇷
First leg: 13/08 (Thursday) at 9:30 p.m. at Gigante de Arroyito, in Argentina
Second leg: 20/08 (Thursday) at 9:30 p.m. at Neo Química Arena
Rosario Central: 2nd in Group H, with 13 points
Corinthians: 1st in Group E, with 11 points
– If Depay really renews his contract with Timão, he could face Ángel Di María in a meeting of veterans with World Cup history. Both played in the 2014 World Cup in Brazil
– The clubs’ only clashes in Libertadores history came in the 2000 round of 16, when Corinthians advanced on penalties
🇧🇷 Cruzeiro x Flamengo 🇧🇷
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First leg: 12/08 (Wednesday) at 9:30 p.m., at Mineirão
Second leg: 19/08 (Wednesday) at 9:30 p.m., at the Maracanã
Cruzeiro: 2nd in Group D, with 11 points
Flamengo: 1st in Group A, with 16 points
– The defending champions Flamengo did not sign any reinforcements for this round, while Cruzeiro have six new names in the squad: left-back Gabriel Rojas, defensive midfielder Zé Lucas, and forwards João Costa, Lucho Rodríguez, Wesley, and Gabriel Pec (the latter has not yet been registered for the Libertadores due to injury)
– It is the only round-of-16 tie between clubs that have already won the Libertadores
🇨🇴 Tolima x Independiente del Valle 🇪🇨
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First leg: 11/08 (Tuesday) at 9:30 p.m. at Estadio Manuel Murillo Toro, in Colombia
Second leg: 18/08 (Tuesday) at 9:30 p.m. at Estadio Banco de Guayaquil, in Ecuador
Tolima: 2nd in Group B, with 8 points
Independiente del Valle: 1st in Group H, with 13 points
– The only tie in this round of 16 without a team from Brazil or Argentina
– Del Valle is the team with the most shots in this Libertadores edition, but has “only” the second-highest number of goals scored, tied with Flamengo (11)
🇧🇷 Mirassol x LDU 🇪🇨
First leg: 13/08 (Thursday) at 7 p.m. at Maião
Second leg: 20/08 (Thursday) at 7 p.m. at Estadio Rodrigo Paz Delgado, in Ecuador
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Mirassol: 2nd in Group G, with 12 points
LDU: 1st in Group G, with 12 points
– It is one of the three round-of-16 ties in which the teams already faced each other in the group stage. Both matches ended 2-0 to the home side
– Brazilian Tiago Nunes was LDU’s coach in the group-stage meetings, but he was sacked in July
🇧🇷 Palmeiras x Cerro Porteño 🇵🇾
First leg: 12/08 (Wednesday) at 7 p.m. at Nubank Parque
Second leg: 19/08 (Wednesday) at 7 p.m. at Estadio General Pablo Rojas, in Paraguay
Palmeiras: 2nd in Group F, with 11 points
Cerro Porteño: 1st in Group F, with 13 points
– It is one of the three round-of-16 ties in which the teams already faced each other in the group stage. There was a draw in Asunción and a Cerro win in São Paulo
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– The clubs will reach 20 Libertadores matches between them. This is the most frequently repeated matchup in the tournament’s history between teams from different countries
🇦🇷 Platense x Coquimbo Unido 🇨🇱
First leg: 12/08 (Wednesday) at 7 p.m. at Estadio Ciudad de Vicente Lopez, in Argentina
Second leg: 19/08 (Wednesday) at 7 p.m. at Estadio Francisco Sánchez Rumoroso, in Chile
Platense: 2nd in Group E, with 10 points
Coquimbo Unido: 1st in Group B, with 10 points
– The only tie this round featuring two teams that have never played in a Libertadores final
– Both clubs won their countries’ national titles for the first time in 2025
🇧🇷 Fluminense x Independiente Rivadavia 🇦🇷
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First leg: 11/08 (Tuesday) at 7 p.m. at the Maracanã
Second leg: 18/08 (Tuesday) at 7 p.m. at Estadio Malvinas Argentinas, in Argentina
Fluminense: 2nd in Group C, with 8 points
Independiente Rivadavia: 1st in Group C, with 16 points
– It is one of the three round-of-16 ties in which the teams already faced each other in the group stage. Tricolor drew in Argentina and lost in Rio
– Rivadavia has the Libertadores top scorer, Alex Arce, with eight goals. Flu’s top scorer in the tournament is injured: John Kennedy, with just two goals
This article was translated into English by Artificial Intelligence. You can read the original version in 🇧🇷 here.
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