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The Buffalo Sabres head to TD Garden with another chance to close out their series against the Boston Bruins in Game 6 tonight.

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My top Sabres vs. Bruins predictions and NHL picks are backing Buffalo to punch its ticket to Round 2 on Friday, May 1.

Sabres vs Bruins Game 6 prediction

Sabres vs Bruins best bet: Sabres moneyline (-115)

Jeremy Swayman stole Game 5 for the Boston Bruins with seven high-danger saves and 2.80 goals saved above expected, and I fully expect a dip from Swayman to allow the Buffalo Sabres to capitalize on enough chances to win Game 6.

Swayman’s scattered just 0.71 GSAx across the other four games of the series, after all.

Buffalo has also dominated the time of possession at 5-on-5 with a 55.6 Corsi For percentage, and the Sabres held the Bruins to just 11 goals and 15.56 expected goals through five games, including only 2.75 xGF at TD Garden.

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Sabres vs Bruins Game 6 same-game parlay

Don’t let some of the high scores in this series fool you. Boston has only scored once in the first period through five games, and four of Buffalo’s five first-period goals came in Game 4. With another elimination game on tap, expect to see attention to defensive detail to be on full display.

Turning to the final leg of this same-game parlay, Alex Tuch has been a force for the Sabres. He found the scoresheet in each of the first four games of the series and has been on the ice for an impressive 8.89 expected goals.

Sabres vs Bruins SGP

  • Under 1.5 first-period goals

  • Alex Tuch Over 0.5 points

Sabres vs Bruins Game 6 goal scorer pick

Jason Zucker (+320)

Buffalo winger Jason Zucker is up to 2.48 individual expected goals and 10 high-danger scoring chances without finding the back of the net in Round 1.

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The eight-time, 20-goal scorer continues to generate quality scoring opportunities, and he’s receiving consistent top-six minutes at 5-on-5 while also jumping the boards with the No. 1 power-play unit, so he’s in the right role to break through in Game 6.

Sabres vs Bruins odds for Game 6

  • Moneyline: Sabres -115 | Bruins -105

  • Puck Line: Sabres -1.5 (+215) | Bruins +1.5 (-265)

  • Over/Under: Over 5.5 (-120) | Under 5.5 (+100)

Sabres vs Bruins trend

The Buffalo Sabres have won 19 of their last 25 away games (+14.25 Units / 50% ROI). Find more NHL betting trends for Sabres vs. Bruins.

How to watch Sabres vs Bruins Game 6

Location

TD Garden, Boston, MA

Date

Friday, May 1, 2026

Puck drop

7:30 p.m. ET

TV

ESPN, Sportsnet 360

Sabres vs Bruins latest injuries

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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