Ohio State vs. Washington prediction, odds, line, time: 2025 college football Week 5 picks by proven model

The top-ranked Ohio State Buckeyes meet the Washington Huskies in Big Ten action on Saturday. Ohio State is coming off a 37-9 win over Ohio, while Washington crushed Washington State 59-24 last weekend. The Buckeyes (3-0), the defending national champions, have won their last seven games dating back to 2024. The Huskies (3-0), who tied for ninth in the Big Ten last year at 4-5 and were 6-7 overall, are 22-0 at home since the start of 2022.

Kickoff from Husky Stadium in Seattle is at 3:30 p.m. ET on CBS and Paramount+. Ohio State leads the all-time series 9-3. The Buckeyes are 8.5-point favorites in the latest Ohio State vs. Washington odds, while the over/under for total points scored is 51.5 via SportsLine consensus. Before making any Washington vs. Ohio State picks, check out the college football predictions from the SportsLine Projection Model. 

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 35-22 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.  

Now, the model has set its sights on Ohio State vs. Washington. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Ohio State vs. Washington:

Why Ohio State can cover

Sophomore quarterback Julian Sayin powers the Buckeyes’ offense. In three games, he has completed 56 of 71 passes (78.9%) for 779 yards and eight touchdowns with three interceptions. In a 14-7 season-opening win over then top-ranked Texas, he completed 13 of 20 passes (65%) for 126 yards and one touchdown. In a 70-0 win over Grambling on Sept. 6, he completed 18 of 19 passes (94.7%) for 306 yards and four touchdowns with one interception.

Sayin’s top target is sophomore wide receiver Jeremiah Smith. Smith has 20 receptions for 315 yards (15.8 average) and three touchdowns. For his career, he has 96 receptions for 1,630 yards and 18 touchdowns. In last week’s win over Ohio, Smith caught nine passes for 153 yards and one touchdown. See which team to back at SportsLine. 

Why Washington can cover

The Huskies are led by sophomore quarterback Demond Williams Jr. He has completed 50 of 68 passes (73.5%) for 778 yards and six touchdowns with zero interceptions. He has also rushed 34 times for 220 yards (6.5 average) and two touchdowns. In last week’s win at Washington State, he completed 16 of 19 passes (84.2%) for 298 yards and four touchdowns.

Fourth-year junior Denzel Boston is the Huskies’ top wide receiver. He has 16 receptions for 249 yards (15.6 average) and three touchdowns. In the win over Washington State, he caught six passes for 107 yards (17.8 average) and two touchdowns. He had five receptions for 92 yards (18.4 average) and one touchdown in a 38-21 win over Colorado State on Aug. 30. See which team to back at SportsLine.

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How to make Ohio State vs. Washington picks

SportsLine’s model is going Under on the total, projecting 48 combined points. It also says one side of the spread hits in well over 50% of simulations. You can only get the pick at SportsLine. 

So who wins Ohio State vs. Washington, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Ohio State vs. Washington spread to jump on, all from the advanced model that finished up over $2,000 on its FBS college football picks since its inception, and find out.