The college football season is in full swing, and conference action heats up on Saturday with several pivotal matchups, including Auburn vs. Oklahoma, Illinois vs. Indiana, Michigan State vs. USC and Michigan vs. Nebraska. The Cornhuskers enter Saturday’s showdown against the Wolverines averaging 49 points per game, which ranks ninth in the nation. Michigan will be without head coach Sherrone Moore on Saturday against Nebraska due to suspension. According to the latest Week 4 college football odds, the Wolverines are still favored by 1.5 points, while the over/under for total points scored is 45.5. SportsLine’s model is backing Michigan, which is 18-2 in its last 20 games played in September, to cover the spread in 63% of simulations at Nebraska.
The model is also backing USC (-17.5) to cover at home against Michigan State, while the Over (57.5) hits 65% of the time in Oregon State vs. Oregon. Other notable Week 4 college football lines include SMU vs. TCU (-7), Texas Tech vs. Utah (-2.5) and Auburn vs. Oklahoma (-6.5). Before locking in your Week 4 college football picks, be sure to check out the top college football betting picks from SportsLine’s proven computer model. New users can also target the all-new DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 32-20 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns, and new users can also target the BetMGM bonus code, which offers up to $1,500 in bonus bets if your first bet loses:
Week 4 college football best bets for Saturday, Sept. 20 (odds subject to change):
- Michigan (-1.5) vs. Nebraska (-115)
- USC (-17.5) vs. Michigan State (-102)
- Over 57.5 points in Oregon State vs. Oregon (-105)
Combining the model’s three picks into a Week 4 college football parlay would result in a payout of +622 (risk $100 to win $622). Bet it now at FanDuel Sportsbook:
Michigan -1.5 vs. Nebraska
The Wolverines have dominated this series in recent years, winning four of the last five meetings against Nebraska, and freshman quarterback Bryce Underwood seems to be finding his footing at the collegiate level. In last week’s 63-3 win over Central Michigan, Underwood completed 16 of 25 passes for 235 yards and a touchdown, while also leading the team in rushing with 114 yards and two scores on nine carries. Meanwhile, Nebraska is 1-5 in its last six meetings against an opponent from the Big Ten. The model is projecting Michigan to cover the spread in 63% of simulations, providing clear value on the spread.
USC -17.5 vs. Michigan State
The Trojans are firing on all cylinders offensively to start the 2025 season. USC is scoring 55 points per game on average, the second-best mark in college football. Michigan State, meanwhile, gave up 40 points to Boston College on Sept. 26, and now the Spartans will face a Trojans offense with explosive playmakers at every position. In addition, Michigan State is 0-8 against the spread in its last eight games and 3-14 in its past 17 games on the road. SportsLine’s model is backing USC to cover the spread in 68% of simulations, targeting the Trojans as one of its top Week 4 college football picks.
Over 57.5 points in Oregon State vs. Oregon
This heated in-state rivalry has been one-sided in recent years, with Oregon winning 17 of the past 20 meetings against Oregon State. The Ducks look like a legitimate national title contender in 2025 thanks to an offense that scores in bunches. The Ducks are averaging 64 points per game at home this season, while Oregon State has given up at least 34 points in every game in 2025. Oregon secured a 49-14 win over Oregon State last season, and SportsLine’s model is projecting these rivals will combine for 67 points on Saturday, helping the Over hit in 65% of simulations.
Want more Week 4 college football picks?
You’ve seen the model’s Week 4 college football best bets for Saturday. Now, get against the spread, total and money-line picks for every Week 4 CFB game here, all from the model that’s simulated every game 10,000 times.
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