Perhaps no team in the nation has been as impressive as South Florida to open the 2025 season. The Bulls have stunned Boise State and Florida thus far as Alex Golesh’s team now has a legitimate path to the College Football Playoff. USF has another chance to pull off a stunner on Saturday when the Bulls take on Miami in a top-20 matchup. The latest Week 3 college football odds list the Hurricanes as 17.5-point favorites.
Other games with potential early CFP implications include Tennessee vs. Georgia (-3.5), LSU vs. Florida (+7.5) and Texas A&M vs. Notre Dame (-7.5). With dozens of college football lines available, what are the best values for college football bets this week? Before locking in any Week 3 college football picks, be sure to see the top Week 3 college football expert picks, predictions and best bets from Thomas Casale.
A frequent guest on national radio and TV shows to discuss college sports, Casale has been sports betting — and winning — for more than 30 years. After going 5-3 so far this season, he’s on a 18-9 roll in his SportsLine best bets column that dates back to last season. Anybody who followed him could have been way up.
Now, he has turned his attention to the Week 3 college football odds and is sharing his top betting picks. If you parlay these college football betting picks, you could be looking at a return of around +600. Get his top college football picks at SportsLine, and new users can also target the DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:
Top Week 3 college football expert predictions
One of Casale’s top Week 3 college football picks: He is backing No. 5 Miami (-17.5) against No. 18. South Florida at 4:30 p.m. ET on Saturday as the Hurricanes look to slow the hard-charging Bulls.
“The issue the Bulls face on Saturday is while Boise State and Florida are good teams, Miami is miles better in the trenches,” Casale told SportsLine. “The Hurricanes have one of the country’s top offensive and defensive lines. We saw that in the opener when the Hurricanes pushed a good Notre Dame defense around and gave up just 93 yards rushing. The other reason I like Miami is because Florida closed -18 and the Hurricanes are -17.5. I have the Hurricanes rated quite a bit higher than the Gators, so last week’s results are creating some value on the number. I took Miami -16.5 and would back the Canes at anything -18 or less.” See what other picks Casale likes at SportsLine.
How to make Week 3 college football picks
Casale has found two other college football picks he loves, including backing an underdog in a game where he says the wrong team is favored. You can only see his picks at SportsLine, and you can use promo code CHAMPIONSHIP to get your first month at SportsLine for just $1.
What are the best bets for Week 3 of college football, and which underdog does Casale believe will win outright? Visit SportsLine now to see Thomas Casale’s college football best bets, all from a proven college football handicapper who is on an 18-9 roll on CFB best bets, and find out.
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